Search on: G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS 
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Descriptor English:   G Protein-Coupled Inwardly-Rectifying Potassium Channels 
Descriptor Spanish:   Canales de Potasio Rectificados Internamente Asociados a la Proteína G 
Descriptor Portuguese:   Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G 
Tree Number:   D12.776.157.530.400.600.450.500
D12.776.543.550.425.750.450.500
D12.776.543.585.400.750.450.500
Definition English:   A family of inwardly-rectifying potassium channels that are activated by PERTUSSIS TOXIN sensitive G-PROTEIN-COUPLED RECEPTORS. GIRK potassium channels are primarily activated by the complex of GTP-BINDING PROTEIN BETA SUBUNITS and GTP-BINDING PROTEIN GAMMA SUBUNITS. 
History Note English:   2006(1993) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50867 
Unique Identifier:   D051676 

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